Assay Detail
Binding
CHEMBL2026428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Flt3
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.89 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1940274 | — | — | 1 | 8.15 |
| CHEMBL1940275 | — | — | 1 | 7.70 |
| CHEMBL2023490 | — | — | 1 | 7.52 |
| CHEMBL2023800 | — | — | 1 | 7.40 |
| CHEMBL2023485 | — | — | 1 | 7.22 |
| CHEMBL2023482 | — | — | 1 | 7.10 |
| CHEMBL2023116 | — | — | 1 | 6.70 |
| CHEMBL2023117 | — | — | 1 | 6.70 |
| CHEMBL2023486 | — | — | 1 | 6.52 |
| CHEMBL2023494 | — | — | 1 | 6.52 |
| CHEMBL2023477 | — | — | 1 | 6.30 |
| CHEMBL2023118 | — | — | 1 | 6.16 |
| CHEMBL2023802 | — | — | 1 | 5.52 |
| CHEMBL2023119 | — | — | 1 | - |
| CHEMBL2023474 | — | — | 1 | - |
| CHEMBL2023475 | — | — | 1 | - |
| CHEMBL2023478 | — | — | 1 | - |
| CHEMBL2023479 | — | — | 1 | - |
| CHEMBL2023480 | — | — | 1 | - |
| CHEMBL2023481 | — | — | 1 | - |
| CHEMBL2023483 | — | — | 1 | - |
| CHEMBL2023484 | — | — | 1 | - |
| CHEMBL2023487 | — | — | 1 | - |
| CHEMBL2023488 | — | — | 1 | - |
| CHEMBL2023491 | — | — | 1 | - |
| CHEMBL2023492 | — | — | 1 | - |
| CHEMBL2023493 | — | — | 1 | - |
| CHEMBL2023496 | — | — | 1 | - |
| CHEMBL2023801 | — | — | 1 | - |
| CHEMBL2023489 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1940274 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1940275 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2023490 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2023800 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2023485 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2023482 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2023116 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2023117 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2023486 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2023494 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2023477 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2023118 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2023802 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2023115 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL2023495 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL2023476 | — | IC50 | > | 900.0 | nM | - |
| CHEMBL2023119 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023474 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023475 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023478 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023479 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023480 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023481 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023483 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023484 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023487 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023488 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023491 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023492 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023493 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023496 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023801 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2023489 | — | IC50 | > | 20000.0 | nM | - |