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Assay Detail

CHEMBL1942993

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Functional
Cytotoxicity against human HL60 cells after 72 hrs by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Influence of the skeleton on the cytotoxicity of flavonoids.
Lewin G, Aubert G, Thoret S, Dubois J, Cresteil T.
Bioorg Med Chem (2012) 20 : 1231 -1239
PubMed 22257529 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 6.98 7.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1643903 1 7.26
CHEMBL126094 1 6.92
CHEMBL1940743 1 6.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1643903 IC50 = 55.0 nM 7.26
CHEMBL126094 IC50 = 120.0 nM 6.92
CHEMBL1940743 IC50 = 180.0 nM 6.75