Assay Detail
Binding
CHEMBL1944479
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Binding affinity to p38alpha MAPK by surface plasmon resonance method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.96 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1938736 | — | — | 1 | 9.40 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 9.00 |
| CHEMBL1938764 | — | — | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1938736 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL103667 | DORAMAPIMOD | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL1938764 | — | Kd | = | 3.3 | nM | 8.48 |