Assay Detail
Binding
CHEMBL1947669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of KATP channel in K+-depolarized rat aortic rings assessed as relaxation of KCl-induced contraction
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 4.56 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946140 | — | — | 1 | 5.12 |
| CHEMBL1946270 | — | — | 1 | 4.76 |
| CHEMBL1946139 | — | — | 1 | 4.75 |
| CHEMBL191539 | — | — | 1 | 4.43 |
| CHEMBL115565 | — | — | 1 | 4.36 |
| CHEMBL1946759 | — | — | 1 | 4.28 |
| CHEMBL1946412 | — | — | 1 | 4.25 |
| CHEMBL1946135 | — | — | 1 | - |
| CHEMBL1945809 | — | — | 1 | - |
| CHEMBL1945806 | — | — | 1 | - |
| CHEMBL1946760 | — | — | 1 | - |
| CHEMBL1944656 | — | — | 1 | - |
| CHEMBL1946413 | — | — | 1 | - |
| CHEMBL1946411 | — | — | 1 | - |
| CHEMBL1946274 | — | — | 1 | - |
| CHEMBL1946138 | — | — | 1 | - |
| CHEMBL1946136 | — | — | 1 | - |
| CHEMBL1946137 | — | — | 1 | - |
| CHEMBL1946271 | — | — | 1 | - |
| CHEMBL1946272 | — | — | 1 | - |
| CHEMBL1945808 | — | — | 1 | - |
| CHEMBL1946414 | — | — | 1 | - |
| CHEMBL1946134 | — | — | 1 | - |
| CHEMBL1945810 | — | — | 1 | - |
| CHEMBL189093 | — | — | 1 | - |
| CHEMBL1946410 | — | — | 1 | - |
| CHEMBL1945807 | — | — | 1 | - |
| CHEMBL1946273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946140 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1946270 | — | EC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL1946139 | — | EC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL191539 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL115565 | — | EC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL1946759 | — | EC50 | = | 53100.0 | nM | 4.28 |
| CHEMBL1946412 | — | EC50 | = | 55700.0 | nM | 4.25 |
| CHEMBL1946135 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL1945809 | — | EC50 | - | — | - | |
| CHEMBL1945806 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL1946760 | — | EC50 | - | — | - | |
| CHEMBL1944656 | — | EC50 | - | — | - | |
| CHEMBL1946413 | — | EC50 | - | — | - | |
| CHEMBL1946411 | — | EC50 | - | — | - | |
| CHEMBL1946274 | — | EC50 | - | — | - | |
| CHEMBL1946138 | — | EC50 | - | — | - | |
| CHEMBL1946136 | — | EC50 | - | — | - | |
| CHEMBL1946137 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL1946271 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL1946272 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL1945808 | — | EC50 | - | — | - | |
| CHEMBL1946414 | — | EC50 | > | 300000.0 | nM | - |
| CHEMBL1946134 | — | EC50 | = | 124000.0 | nM | - |
| CHEMBL1945810 | — | EC50 | = | 189000.0 | nM | - |
| CHEMBL189093 | — | EC50 | = | 274000.0 | nM | - |
| CHEMBL1946410 | — | EC50 | = | 241000.0 | nM | - |
| CHEMBL1945807 | — | EC50 | = | 230000.0 | nM | - |
| CHEMBL1946273 | — | EC50 | > | 200000.0 | nM | - |