Assay Detail
Binding
CHEMBL1948028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX1 in human HEL 92.1.7 cells assessed as thromboxane B2 production incubated for 30 mins before arachidonic acid addition measured after 15 mins by ELISA
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEL |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methyl-monofluorination of ibuprofen selectively increases its inhibitory activity toward cyclooxygenase-1 leading to enhanced analgesic activity and reduced gastric damage in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.96 | 8.91 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1945285 | — | — | 2 | 8.91 |
| CHEMBL175 | DEXIBUPROFEN | 4.0 | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1945285 | — | IC50 | = | 1.23 | nM | 8.91 |
| CHEMBL175 | DEXIBUPROFEN | IC50 | = | 98.65 | nM | 7.01 |
| CHEMBL1945285 | — | Inhibition | - | % | - |