Assay Detail
Binding
CHEMBL1948178
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Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in phosphate buffer by isothermal titration calorimetric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bioanalytical Screening of Riboflavin Antagonists for Targeted Drug Delivery - A Thermodynamic and Kinetic Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.94 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1534 | RIBOFLAVIN | 4.0 | 1 | 8.30 |
| CHEMBL1233985 | LUMIFLAVIN | — | 1 | 7.21 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 6.58 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1534 | RIBOFLAVIN | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL1233985 | LUMIFLAVIN | Kd | = | 61.0 | nM | 7.21 |
| CHEMBL7568 | QUINACRINE | Kd | = | 264.0 | nM | 6.58 |
| CHEMBL76 | CHLOROQUINE | Kd | = | 2100.0 | nM | 5.68 |