Assay Detail
Functional
CHEMBL1948191
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Cytotoxicity against human SU-DHL1 cells expressing ALK coexpressing NPM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SU-DHL-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.03 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1947135 | — | — | 1 | 9.00 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 8.00 |
| CHEMBL1946939 | — | — | 1 | 8.00 |
| CHEMBL1946949 | — | — | 1 | 7.10 |
| CHEMBL509032 | TAE-684 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1947135 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1946939 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1946949 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL509032 | TAE-684 | IC50 | - | — | - |