Assay Detail
Binding
CHEMBL1948411
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 4 esterase activity using 4-nitrophenylacetate as substrate
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 5.46 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.24 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.08 |
| CHEMBL1946088 | — | — | 1 | 6.07 |
| CHEMBL2092897 | — | — | 1 | 6.06 |
| CHEMBL2092896 | — | — | 1 | 6.06 |
| CHEMBL1946177 | — | — | 1 | 6.03 |
| CHEMBL490356 | SYMPHYOKETONE | — | 1 | 5.97 |
| CHEMBL1946178 | — | — | 1 | 5.95 |
| CHEMBL27601 | BENZENESULFONAMIDE | — | 1 | 5.95 |
| CHEMBL1946184 | — | — | 1 | 5.84 |
| CHEMBL1946087 | — | — | 1 | 5.15 |
| CHEMBL1946086 | — | — | 1 | 5.13 |
| CHEMBL1946085 | — | — | 1 | 5.12 |
| CHEMBL1946181 | — | — | 1 | 5.07 |
| CHEMBL1946182 | — | — | 1 | 5.06 |
| CHEMBL1946183 | — | — | 1 | 5.05 |
| CHEMBL1668603 | 1,2-DIMETHOXYBENZENE | — | 1 | 4.84 |
| CHEMBL464987 | — | — | 1 | 4.56 |
| CHEMBL374829 | — | — | 1 | 4.55 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 4.42 |
| CHEMBL1946179 | — | — | 1 | - |
| CHEMBL1946180 | — | — | 1 | - |
| CHEMBL1946084 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 578.0 | nM | 6.24 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL1946088 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL2092897 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL2092896 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL1946177 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL490356 | SYMPHYOKETONE | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL1946178 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL27601 | BENZENESULFONAMIDE | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL1946184 | — | Ki | = | 1430.0 | nM | 5.84 |
| CHEMBL1946087 | — | Ki | = | 7030.0 | nM | 5.15 |
| CHEMBL1946086 | — | Ki | = | 7420.0 | nM | 5.13 |
| CHEMBL1946085 | — | Ki | = | 7680.0 | nM | 5.12 |
| CHEMBL1946181 | — | Ki | = | 8430.0 | nM | 5.07 |
| CHEMBL1946182 | — | Ki | = | 8670.0 | nM | 5.06 |
| CHEMBL1946183 | — | Ki | = | 8930.0 | nM | 5.05 |
| CHEMBL1668603 | 1,2-DIMETHOXYBENZENE | Ki | = | 14320.0 | nM | 4.84 |
| CHEMBL464987 | — | Ki | = | 27480.0 | nM | 4.56 |
| CHEMBL374829 | — | Ki | = | 28040.0 | nM | 4.55 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 38450.0 | nM | 4.42 |
| CHEMBL1946179 | — | Ki | = | 163360.0 | nM | - |
| CHEMBL1946180 | — | Ki | = | 104410.0 | nM | - |
| CHEMBL1946084 | — | Ki | = | 102400.0 | nM | - |