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Assay Detail

CHEMBL1948412

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human carbonic anhydrase 1 esterase activity using 4-nitrophenylacetate as substrate
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 1 (CHEMBL261)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.
Balaydın HT, Sentürk M, Menzek A.
Bioorg Med Chem Lett (2012) 22 : 1352 -1357
PubMed 22230050 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 5.19 5.99

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2092896 1 5.99
CHEMBL1946088 1 5.98
CHEMBL2092897 1 5.96
CHEMBL1946177 1 5.95
CHEMBL490356 SYMPHYOKETONE 1 5.78
CHEMBL1946178 1 5.61
CHEMBL18 ETHOXZOLAMIDE 4.0 1 5.43
CHEMBL1946182 1 5.12
CHEMBL1946181 1 5.12
CHEMBL1946183 1 5.07
CHEMBL1946087 1 4.98
CHEMBL27601 BENZENESULFONAMIDE 1 4.91
CHEMBL1946086 1 4.89
CHEMBL1946085 1 4.88
CHEMBL1946184 1 4.84
CHEMBL750 ZONISAMIDE 4.0 1 4.83
CHEMBL464987 1 4.46
CHEMBL374829 1 4.45
CHEMBL20 ACETAZOLAMIDE 4.0 1 4.44
CHEMBL1946180 1 -
CHEMBL1946179 1 -
CHEMBL1946084 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2092896 Ki = 1030.0 nM 5.99
CHEMBL1946088 Ki = 1040.0 nM 5.98
CHEMBL2092897 Ki = 1100.0 nM 5.96
CHEMBL1946177 Ki = 1120.0 nM 5.95
CHEMBL490356 SYMPHYOKETONE Ki = 1670.0 nM 5.78
CHEMBL1946178 Ki = 2450.0 nM 5.61
CHEMBL18 ETHOXZOLAMIDE Ki = 3750.0 nM 5.43
CHEMBL1946182 Ki = 7640.0 nM 5.12
CHEMBL1946181 Ki = 7560.0 nM 5.12
CHEMBL1946183 Ki = 8610.0 nM 5.07
CHEMBL1946087 Ki = 10540.0 nM 4.98
CHEMBL27601 BENZENESULFONAMIDE Ki = 12360.0 nM 4.91
CHEMBL1946086 Ki = 12920.0 nM 4.89
CHEMBL1946085 Ki = 13270.0 nM 4.88
CHEMBL1946184 Ki = 14480.0 nM 4.84
CHEMBL750 ZONISAMIDE Ki = 14800.0 nM 4.83
CHEMBL464987 Ki = 34410.0 nM 4.46
CHEMBL374829 Ki = 35120.0 nM 4.45
CHEMBL20 ACETAZOLAMIDE Ki = 36200.0 nM 4.44
CHEMBL1946180 Ki = 193240.0 nM -
CHEMBL1946179 Ki = 292109.0 nM -
CHEMBL1946084 Ki = 187130.0 nM -