Assay Detail
Binding
CHEMBL1948413
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine binding protein expressed using baculoviral system after 1.5 hrs by scintillation counting
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lymnaea stagnalis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.29 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1947055 | — | — | 1 | 7.50 |
| CHEMBL1946189 | — | — | 1 | 7.40 |
| CHEMBL1947053 | — | — | 1 | 7.10 |
| CHEMBL1947206 | — | — | 1 | 7.00 |
| CHEMBL1946188 | — | — | 1 | 7.00 |
| CHEMBL1947060 | — | — | 1 | 6.90 |
| CHEMBL1947059 | — | — | 1 | 6.90 |
| CHEMBL1794606 | — | — | 1 | 6.60 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 6.50 |
| CHEMBL1946187 | — | — | 1 | 6.50 |
| CHEMBL1947062 | — | — | 1 | 6.40 |
| CHEMBL1947054 | — | — | 1 | 6.40 |
| CHEMBL1947056 | — | — | 1 | 6.20 |
| CHEMBL122270 | LOBELINE | 2.0 | 1 | 6.20 |
| CHEMBL1947049 | — | — | 1 | 6.10 |
| CHEMBL1947058 | — | — | 1 | 6.10 |
| CHEMBL1947061 | — | — | 1 | 6.10 |
| CHEMBL1946185 | — | — | 1 | 6.00 |
| CHEMBL1947057 | — | — | 1 | 5.90 |
| CHEMBL1947051 | BENZOYL TROPINE | — | 1 | 5.70 |
| CHEMBL1947048 | — | — | 1 | 5.70 |
| CHEMBL1947047 | — | — | 1 | 5.70 |
| CHEMBL1946186 | DEPTROPINE | 2.0 | 1 | 5.70 |
| CHEMBL1947205 | — | — | 1 | 5.70 |
| CHEMBL1947052 | — | — | 1 | 5.20 |
| CHEMBL1947050 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1947055 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1946189 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL1947053 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL1947206 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1946188 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1947060 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL1947059 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL1794606 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL3 | NICOTINE | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL1946187 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL1947062 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL1947054 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL1947056 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL122270 | LOBELINE | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL1947049 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL1947058 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL1947061 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL1946185 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1947057 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL1947051 | BENZOYL TROPINE | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL1947048 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL1947047 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL1946186 | DEPTROPINE | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL1947205 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL1947052 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL1947050 | — | Ki | = | 7943.28 | nM | 5.10 |