Assay Detail
Binding
CHEMBL1948475
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from human recombinant alpha1B adrenoceptor expressed in CHO cells after 30 mins by liquid scintillation counting
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.10 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946777 | — | — | 1 | 8.17 |
| CHEMBL1946780 | — | — | 1 | 8.05 |
| CHEMBL1946779 | — | — | 1 | 7.40 |
| CHEMBL286003 | — | — | 1 | 7.33 |
| CHEMBL37883 | — | — | 1 | 7.20 |
| CHEMBL514874 | — | — | 1 | 7.18 |
| CHEMBL1946786 | — | — | 1 | 7.13 |
| CHEMBL1946778 | — | — | 1 | 6.91 |
| CHEMBL1946783 | — | — | 1 | 6.85 |
| CHEMBL1946787 | — | — | 1 | 6.78 |
| CHEMBL1946788 | — | — | 1 | 6.61 |
| CHEMBL1946785 | — | — | 1 | 6.54 |
| CHEMBL13647 | BMY-7378 | — | 1 | 6.15 |
| CHEMBL1946781 | — | — | 1 | - |
| CHEMBL1946782 | — | — | 1 | - |
| CHEMBL1946784 | — | — | 1 | - |
| CHEMBL56 | 8-OH-DPAT | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946777 | — | Ki | = | 6.761 | nM | 8.17 |
| CHEMBL1946780 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL1946779 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL286003 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL37883 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL514874 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL1946786 | — | Ki | = | 74.13 | nM | 7.13 |
| CHEMBL1946778 | — | Ki | = | 123.03 | nM | 6.91 |
| CHEMBL1946783 | — | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL1946787 | — | Ki | = | 165.96 | nM | 6.78 |
| CHEMBL1946788 | — | Ki | = | 245.47 | nM | 6.61 |
| CHEMBL1946785 | — | Ki | = | 288.4 | nM | 6.54 |
| CHEMBL13647 | BMY-7378 | Ki | = | 707.95 | nM | 6.15 |
| CHEMBL1946781 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1946782 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1946784 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL56 | 8-OH-DPAT | Ki | > | 1000.0 | nM | - |