Assay Detail
Binding
CHEMBL1948548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 4 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.69 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL593507 | — | — | 1 | 6.36 |
| CHEMBL593667 | — | — | 1 | 6.27 |
| CHEMBL596277 | — | — | 1 | 6.26 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.24 |
| CHEMBL593759 | — | — | 1 | 6.21 |
| CHEMBL607823 | — | — | 1 | 6.12 |
| CHEMBL595861 | — | — | 1 | 6.11 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.08 |
| CHEMBL594918 | — | — | 1 | 6.08 |
| CHEMBL610454 | — | — | 1 | 6.06 |
| CHEMBL593972 | — | — | 1 | 6.04 |
| CHEMBL611504 | — | — | 1 | 6.03 |
| CHEMBL596276 | — | — | 1 | 5.99 |
| CHEMBL122708 | EMATE | — | 1 | 5.98 |
| CHEMBL15844 | INDOLE | — | 1 | 5.63 |
| CHEMBL607824 | — | — | 1 | 5.39 |
| CHEMBL607813 | — | — | 1 | 5.38 |
| CHEMBL610455 | — | — | 1 | 5.35 |
| CHEMBL611502 | — | — | 1 | 5.34 |
| CHEMBL596060 | — | — | 1 | 5.33 |
| CHEMBL593276 | — | — | 1 | 5.33 |
| CHEMBL593037 | — | — | 1 | 5.31 |
| CHEMBL608978 | — | — | 1 | 5.27 |
| CHEMBL594224 | — | — | 1 | 5.24 |
| CHEMBL280998 | CATECHOL | — | 1 | 4.96 |
| CHEMBL1668603 | 1,2-DIMETHOXYBENZENE | — | 1 | 4.84 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL593507 | — | Ki | = | 435.0 | nM | 6.36 |
| CHEMBL593667 | — | Ki | = | 532.0 | nM | 6.27 |
| CHEMBL596277 | — | Ki | = | 543.0 | nM | 6.26 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 578.0 | nM | 6.24 |
| CHEMBL593759 | — | Ki | = | 617.0 | nM | 6.21 |
| CHEMBL607823 | — | Ki | = | 765.0 | nM | 6.12 |
| CHEMBL595861 | — | Ki | = | 778.0 | nM | 6.11 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL594918 | — | Ki | = | 842.0 | nM | 6.08 |
| CHEMBL610454 | — | Ki | = | 875.0 | nM | 6.06 |
| CHEMBL593972 | — | Ki | = | 912.0 | nM | 6.04 |
| CHEMBL611504 | — | Ki | = | 943.0 | nM | 6.03 |
| CHEMBL596276 | — | Ki | = | 1032.0 | nM | 5.99 |
| CHEMBL122708 | EMATE | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL15844 | INDOLE | Ki | = | 2330.0 | nM | 5.63 |
| CHEMBL607824 | — | Ki | = | 4082.0 | nM | 5.39 |
| CHEMBL607813 | — | Ki | = | 4215.0 | nM | 5.38 |
| CHEMBL610455 | — | Ki | = | 4442.0 | nM | 5.35 |
| CHEMBL611502 | — | Ki | = | 4573.0 | nM | 5.34 |
| CHEMBL596060 | — | Ki | = | 4736.0 | nM | 5.33 |
| CHEMBL593276 | — | Ki | = | 4627.0 | nM | 5.33 |
| CHEMBL593037 | — | Ki | = | 4852.0 | nM | 5.31 |
| CHEMBL608978 | — | Ki | = | 5341.0 | nM | 5.27 |
| CHEMBL594224 | — | Ki | = | 5726.0 | nM | 5.24 |
| CHEMBL280998 | CATECHOL | Ki | = | 10900.0 | nM | 4.96 |
| CHEMBL1668603 | 1,2-DIMETHOXYBENZENE | Ki | = | 14320.0 | nM | 4.84 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 38450.0 | nM | 4.42 |