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Assay Detail

CHEMBL1948903

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type MRC5
Confidence 1 — Organism
Curated By Autocuration

Target

MRC5 (CHEMBL614181)
Type CELL-LINE
Organism Homo sapiens

Publication

Quinol derivatives as potential trypanocidal agents.
Capes A, Patterson S, Wyllie S, Hallyburton I, Collie IT, McCarroll AJ, Stevens MF, Frearson JA, Wyatt PG, Fairlamb AH, Gilbert IH.
Bioorg Med Chem (2012) 20 : 1607 -1615
PubMed 22264753 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 31 6.60 7.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL222039 1 7.44
CHEMBL222690 1 7.41
CHEMBL374005 1 7.39
CHEMBL374365 1 7.36
CHEMBL1945422 1 7.30
CHEMBL1945231 1 7.29
CHEMBL1945420 1 7.28
CHEMBL151101 1 7.26
CHEMBL1945419 1 7.17
CHEMBL1945228 1 7.16
CHEMBL1945421 1 7.10
CHEMBL225016 1 7.07
CHEMBL177916 1 6.96
CHEMBL376532 1 6.77
CHEMBL151831 1 6.75
CHEMBL222088 1 6.55
CHEMBL1944644 1 6.51
CHEMBL1945227 1 6.35
CHEMBL1945226 1 6.17
CHEMBL1944646 1 6.02
CHEMBL356615 1 5.96
CHEMBL149352 1 5.77
CHEMBL1945118 1 5.68
CHEMBL223812 1 5.48
CHEMBL1945230 1 4.75
CHEMBL1945425 1 4.75
CHEMBL1945229 1 -
CHEMBL47875 1 -
CHEMBL1945423 1 -
CHEMBL1945424 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL222039 EC50 = 36.0 nM 7.44
CHEMBL222690 EC50 = 39.0 nM 7.41
CHEMBL374005 EC50 = 41.0 nM 7.39
CHEMBL374365 EC50 = 44.0 nM 7.36
CHEMBL1945422 EC50 = 50.0 nM 7.30
CHEMBL1945231 EC50 = 51.0 nM 7.29
CHEMBL1945420 EC50 = 52.0 nM 7.28
CHEMBL151101 EC50 = 55.0 nM 7.26
CHEMBL1945419 EC50 = 67.0 nM 7.17
CHEMBL1945228 EC50 = 69.0 nM 7.16
CHEMBL1945421 EC50 = 79.0 nM 7.10
CHEMBL225016 EC50 = 86.0 nM 7.07
CHEMBL177916 EC50 = 110.0 nM 6.96
CHEMBL376532 EC50 = 170.0 nM 6.77
CHEMBL151831 EC50 = 180.0 nM 6.75
CHEMBL222088 EC50 = 280.0 nM 6.55
CHEMBL1944644 EC50 = 310.0 nM 6.51
CHEMBL1945227 EC50 = 450.0 nM 6.35
CHEMBL1945226 EC50 = 670.0 nM 6.17
CHEMBL1944646 EC50 = 950.0 nM 6.02
CHEMBL356615 EC50 = 1100.0 nM 5.96
CHEMBL149352 EC50 = 1700.0 nM 5.77
CHEMBL1945118 EC50 = 2100.0 nM 5.68
CHEMBL223812 EC50 = 3300.0 nM 5.48
CHEMBL1945230 EC50 = 18000.0 nM 4.75
CHEMBL1945425 EC50 = 18000.0 nM 4.75
CHEMBL1945229 EC50 > 50000.0 nM -
CHEMBL47875 EC50 > 50000.0 nM -
CHEMBL1945423 EC50 > 50000.0 nM -
CHEMBL1945424 EC50 > 50000.0 nM -
CHEMBL35241 DIMINAZENE EC50 - -