Assay Detail
Binding
CHEMBL1948973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Low molecular weight protein-tyrosine phosphatase A (CHEMBL4542) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.20 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1945186 | — | — | 1 | 4.82 |
| CHEMBL1946281 | — | — | 1 | 4.50 |
| CHEMBL455469 | — | — | 1 | 4.35 |
| CHEMBL455453 | — | — | 1 | 4.21 |
| CHEMBL1946982 | — | — | 1 | 4.18 |
| CHEMBL1946981 | — | — | 1 | 4.13 |
| CHEMBL1946988 | — | — | 1 | 4.08 |
| CHEMBL1945552 | — | — | 1 | 4.03 |
| CHEMBL1098610 | — | — | 1 | 4.03 |
| CHEMBL1946992 | — | — | 1 | 4.03 |
| CHEMBL1946997 | — | — | 1 | 4.03 |
| CHEMBL1946279 | — | — | 1 | 4.00 |
| CHEMBL1945997 | — | — | 1 | - |
| CHEMBL1945999 | — | — | 1 | - |
| CHEMBL1946001 | — | — | 1 | - |
| CHEMBL519069 | — | — | 1 | - |
| CHEMBL1946280 | — | — | 1 | - |
| CHEMBL1946282 | — | — | 1 | - |
| CHEMBL1946285 | — | — | 1 | - |
| CHEMBL1946439 | — | — | 1 | - |
| CHEMBL1946440 | — | — | 1 | - |
| CHEMBL1946984 | — | — | 1 | - |
| CHEMBL1946985 | — | — | 1 | - |
| CHEMBL1946986 | — | — | 1 | - |
| CHEMBL1288972 | — | — | 1 | - |
| CHEMBL1946990 | — | — | 1 | - |
| CHEMBL1945185 | — | — | 1 | - |
| CHEMBL1946993 | — | — | 1 | - |
| CHEMBL1945187 | — | — | 1 | - |
| CHEMBL1946998 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1945186 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1946281 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL455469 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL455453 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL1946982 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL1946981 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL1946988 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL1946997 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL1946992 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL1098610 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL1945552 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL1946279 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1945702 | — | IC50 | = | 101000.0 | nM | - |
| CHEMBL1096287 | — | IC50 | - | — | - | |
| CHEMBL1945996 | — | IC50 | = | 1023000.0 | nM | - |
| CHEMBL1945997 | — | IC50 | = | 1659000.0 | nM | - |
| CHEMBL1945999 | — | IC50 | = | 331000.0 | nM | - |
| CHEMBL1946001 | — | IC50 | - | — | - | |
| CHEMBL519069 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1946280 | — | IC50 | - | — | - | |
| CHEMBL1946282 | — | IC50 | = | 302000.0 | nM | - |
| CHEMBL1946285 | — | IC50 | = | 151000.0 | nM | - |
| CHEMBL1946439 | — | IC50 | - | — | - | |
| CHEMBL1946440 | — | IC50 | = | 169000.0 | nM | - |
| CHEMBL1946984 | — | IC50 | = | 155000.0 | nM | - |
| CHEMBL1946985 | — | IC50 | = | 407000.0 | nM | - |
| CHEMBL1946986 | — | IC50 | = | 174000.0 | nM | - |
| CHEMBL1288972 | — | IC50 | = | 117000.0 | nM | - |
| CHEMBL1946990 | — | IC50 | - | — | - | |
| CHEMBL1945185 | — | IC50 | - | — | - | |
| CHEMBL1946993 | — | IC50 | = | 214000.0 | nM | - |
| CHEMBL1945187 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL1946998 | — | IC50 | > | 100000.0 | nM | - |