Assay Detail
Binding
CHEMBL1948978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by Lineweaver-Burk plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Low molecular weight protein-tyrosine phosphatase A (CHEMBL4542) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.70 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1945186 | — | — | 1 | 4.92 |
| CHEMBL1946281 | — | — | 1 | 4.64 |
| CHEMBL455469 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1945186 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL1946281 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL455469 | — | Ki | = | 29000.0 | nM | 4.54 |