Assay Detail
Binding
CHEMBL1948979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by Lineweaver-Burk plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphotyrosine-protein phosphatase PTPB (CHEMBL4540) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.00 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946998 | — | — | 1 | 5.10 |
| CHEMBL519069 | — | — | 1 | 5.00 |
| CHEMBL455453 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946998 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL519069 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL455453 | — | Ki | = | 13000.0 | nM | 4.89 |