Assay Detail
Functional
CHEMBL1949182
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Cytotoxicity against human CEM cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.85 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.30 |
| CHEMBL373114 | LAMELLARIN D | — | 1 | 4.82 |
| CHEMBL1946917 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL373114 | LAMELLARIN D | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1946917 | — | IC50 | = | 38500.0 | nM | 4.42 |