Assay Detail
Binding
CHEMBL1949352
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Inhibition of EGFR after 50 mins by HTRF assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of quinazoline and quinoline bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors and EPR bio-probe agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.65 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 8.14 |
| CHEMBL1947124 | — | — | 1 | 7.82 |
| CHEMBL242541 | — | — | 1 | 7.54 |
| CHEMBL1946926 | — | — | 1 | 7.51 |
| CHEMBL52765 | — | — | 1 | 7.28 |
| CHEMBL1947125 | — | — | 1 | 7.19 |
| CHEMBL343352 | — | — | 1 | 6.72 |
| CHEMBL1947127 | — | — | 1 | 6.47 |
| CHEMBL1947121 | — | — | 1 | 6.38 |
| CHEMBL1947126 | — | — | 1 | 6.21 |
| CHEMBL541988 | — | — | 1 | 5.06 |
| CHEMBL1947122 | — | — | 1 | 5.04 |
| CHEMBL1947123 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL939 | GEFITINIB | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL1947124 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL242541 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1946926 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL52765 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1947125 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL343352 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL1947127 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL1947121 | — | IC50 | = | 422.0 | nM | 6.38 |
| CHEMBL1947126 | — | IC50 | = | 623.0 | nM | 6.21 |
| CHEMBL541988 | — | IC50 | = | 8719.0 | nM | 5.06 |
| CHEMBL1947122 | — | IC50 | = | 9021.0 | nM | 5.04 |
| CHEMBL1947123 | — | IC50 | = | 9284.0 | nM | 5.03 |