Assay Detail
Functional
CHEMBL1949353
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Cytotoxicity against human A431 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of quinazoline and quinoline bearing 2,2,6,6-tetramethylpiperidine-N-oxyl as potential epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors and EPR bio-probe agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.36 | 4.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1947124 | — | — | 1 | 4.61 |
| CHEMBL1947125 | — | — | 1 | 4.57 |
| CHEMBL1946926 | — | — | 1 | 4.56 |
| CHEMBL343352 | — | — | 1 | 4.50 |
| CHEMBL52765 | — | — | 1 | 4.46 |
| CHEMBL1947121 | — | — | 1 | 4.42 |
| CHEMBL1947127 | — | — | 1 | 4.36 |
| CHEMBL1947126 | — | — | 1 | 4.34 |
| CHEMBL1947123 | — | — | 1 | 4.05 |
| CHEMBL541988 | — | — | 1 | 4.03 |
| CHEMBL1947122 | — | — | 1 | 4.01 |
| CHEMBL606971 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1947124 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL1947125 | — | IC50 | = | 26850.0 | nM | 4.57 |
| CHEMBL1946926 | — | IC50 | = | 27380.0 | nM | 4.56 |
| CHEMBL343352 | — | IC50 | = | 31940.0 | nM | 4.50 |
| CHEMBL52765 | — | IC50 | = | 34890.0 | nM | 4.46 |
| CHEMBL1947121 | — | IC50 | = | 38140.0 | nM | 4.42 |
| CHEMBL1947127 | — | IC50 | = | 43210.0 | nM | 4.36 |
| CHEMBL1947126 | — | IC50 | = | 45460.0 | nM | 4.34 |
| CHEMBL1947123 | — | IC50 | = | 88830.0 | nM | 4.05 |
| CHEMBL541988 | — | IC50 | = | 93990.0 | nM | 4.03 |
| CHEMBL1947122 | — | IC50 | = | 97850.0 | nM | 4.01 |
| CHEMBL606971 | — | IC50 | > | 300000.0 | nM | - |