Assay Detail
Binding
CHEMBL1949471
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-N-methylspiperone from rat dopamine D4 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.96 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946123 | — | — | 1 | 8.03 |
| CHEMBL1946254 | — | — | 1 | 7.54 |
| CHEMBL1946125 | — | — | 1 | 7.49 |
| CHEMBL1946124 | — | — | 1 | 7.43 |
| CHEMBL1946122 | — | — | 1 | 7.31 |
| CHEMBL1946126 | — | — | 1 | 6.96 |
| CHEMBL1946253 | — | — | 1 | 6.91 |
| CHEMBL1946258 | — | — | 1 | 6.90 |
| CHEMBL1946255 | — | — | 1 | 6.37 |
| CHEMBL1946745 | — | — | 1 | 6.37 |
| CHEMBL1946744 | — | — | 1 | 6.29 |
| CHEMBL1946257 | — | — | 1 | 5.92 |
| CHEMBL1946256 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946123 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL1946254 | — | Ki | = | 28.6 | nM | 7.54 |
| CHEMBL1946125 | — | Ki | = | 32.1 | nM | 7.49 |
| CHEMBL1946124 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1946122 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL1946126 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL1946253 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL1946258 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL1946255 | — | Ki | = | 431.0 | nM | 6.37 |
| CHEMBL1946745 | — | Ki | = | 432.0 | nM | 6.37 |
| CHEMBL1946744 | — | Ki | = | 508.0 | nM | 6.29 |
| CHEMBL1946257 | — | Ki | = | 1215.0 | nM | 5.92 |
| CHEMBL1946256 | — | Ki | - | — | - |