Assay Detail
Functional
CHEMBL1953095
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse MMTV-Wnt-1 cells assessed as cell viability after 72 hrs by DAPI staining method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of leukemia and cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.97 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176252 | — | — | 1 | 7.33 |
| CHEMBL1950949 | — | — | 1 | 7.31 |
| CHEMBL1950948 | — | — | 1 | 7.21 |
| CHEMBL1950947 | — | — | 1 | 7.20 |
| CHEMBL1950943 | — | — | 1 | 7.14 |
| CHEMBL1950942 | — | — | 1 | 5.62 |
| CHEMBL1950944 | — | — | 1 | - |
| CHEMBL1950945 | — | — | 1 | - |
| CHEMBL1950946 | — | — | 1 | - |
| CHEMBL1950950 | — | — | 1 | - |
| CHEMBL1950951 | — | — | 1 | - |
| CHEMBL1950952 | — | — | 1 | - |
| CHEMBL1950953 | — | — | 1 | - |
| CHEMBL1950954 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176252 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1950949 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1950948 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1950947 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1950943 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1950942 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL1950944 | — | IC50 | - | — | - | |
| CHEMBL1950945 | — | IC50 | - | — | - | |
| CHEMBL1950946 | — | IC50 | - | — | - | |
| CHEMBL1950950 | — | IC50 | - | — | - | |
| CHEMBL1950951 | — | IC50 | - | — | - | |
| CHEMBL1950952 | — | IC50 | - | — | - | |
| CHEMBL1950953 | — | IC50 | - | — | - | |
| CHEMBL1950954 | — | IC50 | - | — | - |