Assay Detail
Binding
CHEMBL1953151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]LSD from rat recombinant 5HT6 receptor
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT₆ receptor antagonist showing activity in rat social recognition test.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.87 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1949930 | — | — | 2 | 7.57 |
| CHEMBL1949764 | — | — | 1 | 7.40 |
| CHEMBL1949763 | — | — | 1 | 7.28 |
| CHEMBL1949762 | — | — | 1 | 6.87 |
| CHEMBL1949760 | — | — | 1 | 6.84 |
| CHEMBL1949768 | — | — | 1 | 6.81 |
| CHEMBL1949773 | — | — | 2 | 6.76 |
| CHEMBL1949761 | — | — | 1 | 6.69 |
| CHEMBL1949772 | — | — | 1 | 6.63 |
| CHEMBL1949765 | — | — | 1 | 6.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1949930 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1949764 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL1949763 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL1949930 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL1949762 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL1949760 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL1949768 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL1949773 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL1949761 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL1949772 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL1949765 | — | Ki | = | 243.0 | nM | 6.61 |
| CHEMBL1949773 | — | Ki | = | 2181.0 | nM | 5.66 |