Compound Detail
CHEMBL1949760
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1949760 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SMMZIHXPNWERBO-LINSIKMZSA-N |
| Parent Compound | CHEMBL1962943 |
| Active Moiety | CHEMBL1962943 |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
333.4
MW (Da)
2.50
ALogP
4
HBA
1
HBD
55.4
PSA (Ų)
0.92
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.5
IC50 1 meas. best 6.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 7.5 | 7.5 | 32.0 | 1 |
| 5-hydroxytryptamine receptor 6 CHEMBL3372 | Ki | 6.84 | 6.84 | 145.0 | 1 |
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | IC50 | 6.75 | 6.75 | 179.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | Ki | = | 32.0 | nM | 7.5 | Displacement of [3H]LSD from human recombinant 5HT6 receptor | 22226656 |
| 5-hydroxytryptamine receptor 6 | Ki | = | 145.0 | nM | 6.84 | Displacement of [3H]LSD from rat recombinant 5HT6 receptor | 22226656 |
| 5-hydroxytryptamine receptor 6 | IC50 | = | 179.0 | nM | 6.75 | Antagonist activity at human 5HT6 receptor expressed in human astrocytoma cells ... | 22226656 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22226656 | 10.1016/j.bmcl.2011.12.026 | 5-hydroxytryptamine receptor 6 | 3 |
Data from ChEMBL 36 via Core Engine