Assay Detail
Functional
CHEMBL1953152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human 5HT6 receptor expressed in human astrocytoma cells assessed as inhibition of cAMP production
18
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT₆ receptor antagonist showing activity in rat social recognition test.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.92 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1949928 | — | — | 2 | 8.22 |
| CHEMBL1949764 | — | — | 1 | 7.57 |
| CHEMBL1949763 | — | — | 1 | 7.48 |
| CHEMBL1949930 | — | — | 2 | 7.35 |
| CHEMBL1949927 | — | — | 2 | 7.20 |
| CHEMBL1949773 | — | — | 2 | 7.02 |
| CHEMBL1949761 | — | — | 1 | 6.88 |
| CHEMBL1949762 | — | — | 1 | 6.87 |
| CHEMBL1949760 | — | — | 1 | 6.75 |
| CHEMBL1949765 | — | — | 1 | 6.64 |
| CHEMBL1949772 | — | — | 1 | 6.61 |
| CHEMBL1949767 | — | — | 1 | 6.55 |
| CHEMBL1949768 | — | — | 1 | 6.51 |
| CHEMBL1949766 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1949928 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1949764 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1949763 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1949928 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1949930 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1949927 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1949930 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1949773 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL1949761 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL1949762 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL1949760 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL1949765 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL1949772 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL1949767 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL1949768 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL1949766 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL1949927 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL1949773 | — | IC50 | = | 1363.0 | nM | 5.87 |