Compound Detail
CHEMBL1949928
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Basic Information
| ChEMBL ID | CHEMBL1949928 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QFKFWVFVZSODOD-NXCSSKFKSA-N |
| Parent Compound | CHEMBL1962959 |
| Active Moiety | CHEMBL1962959 |
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
384.3
MW (Da)
3.66
ALogP
4
HBA
1
HBD
55.4
PSA (Ų)
0.86
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.22
Ki 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 8.7 | 8.5 | 2.0 | 2 |
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | IC50 | 8.22 | 7.81 | 6.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | Ki | = | 2.0 | nM | 8.7 | Displacement of [3H]LSD from human recombinant 5HT6 receptor | 22226656 |
| 5-hydroxytryptamine receptor 6 | Ki | = | 5.0 | nM | 8.3 | Displacement of [3H]LSD from human recombinant 5HT6 receptor | 22226656 |
| 5-hydroxytryptamine receptor 6 | IC50 | = | 6.0 | nM | 8.22 | Antagonist activity at human 5HT6 receptor expressed in human astrocytoma cells ... | 22226656 |
| 5-hydroxytryptamine receptor 6 | IC50 | = | 40.0 | nM | 7.4 | Antagonist activity at human 5HT6 receptor expressed in human astrocytoma cells ... | 22226656 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22226656 | 10.1016/j.bmcl.2011.12.026 | 5-hydroxytryptamine receptor 6 | 4 |
Data from ChEMBL 36 via Core Engine