Assay Detail

CHEMBL1953593

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Binding

Inhibition of Escherichia coli ribosome-mediated translation after 60 mins by transcription/translation-coupled luciferase reporter gene assay

ChEMBL ↗

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Target

Bacterial 70S ribosome (CHEMBL2363135) ↗

Open DB target context

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Bacterial 70S ribosome (CHEMBL2363135) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Bacterial 70S ribosome

CHEMBL2363135

Anchored from Assay target.

Protein identity Bacterial 70S ribosome

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Escherichia coli
Subcellular	Ribosome
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Bacterial 70S ribosome (CHEMBL2363135) ↗

Type	PROTEIN NUCLEIC-ACID COMPLEX
Organism	Bacteria

Publication

Fluorocyclines. 1. 7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: a potent, broad spectrum antibacterial agent.

Xiao XY, Hunt DK, Zhou J, Clark RB, Dunwoody N, Fyfe C, Grossman TH, O'Brien WJ, Plamondon L, Rönn M, Sun C, Zhang WY, Sutcliffe JA.
J Med Chem (2012) 55 : 597 -605
PubMed 22148514 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.78	6.21

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1951095	ERAVACYCLINE	4.0	1	6.21
CHEMBL1440	TETRACYCLINE	4.0	1	5.34

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1951095	ERAVACYCLINE	IC50	=	620.0	nM	6.21
CHEMBL1440	TETRACYCLINE	IC50	=	4580.0	nM	5.34