Assay Detail

CHEMBL1955250

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Functional

Cytotoxicity against human HL60 cells after 24 hrs by MTT assay

ChEMBL ↗

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Target

HL-60 (CHEMBL383) ↗

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Primary target HL-60

CHEMBL383

Anchored from Assay target.

Protein identity HL-60

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HL-60
Confidence	1 — Organism
Curated By	Autocuration

Target

HL-60 (CHEMBL383) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Induction of apoptosis in HL-60 cells through the ROS-mediated mitochondrial pathway by ramentaceone from Drosera aliciae.

Kawiak A, Zawacka-Pankau J, Wasilewska A, Stasilojc G, Bigda J, Lojkowska E.
J Nat Prod (2012) 75 : 9 -14
PubMed 22250825 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Activity	1	-	-
IC50	1	5.06	5.06

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL430853	RAMENTACEONE	—	2	5.06

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL430853	RAMENTACEONE	IC50	=	8750.0	nM	5.06
CHEMBL430853	RAMENTACEONE	Activity		-	—	-