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Assay Detail

CHEMBL1955474

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Functional
Antiproliferative activity against human WHCO1 cells after 48 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type WHCO1
Confidence 1 — Organism
Curated By Autocuration

Publication

Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells.
Kaschula CH, Hunter R, Stellenboom N, Caira MR, Winks S, Ogunleye T, Richards P, Cotton J, Zilbeyaz K, Wang Y, Siyo V, Ngarande E, Parker MI.
Eur J Med Chem (2012) 50 : 236 -254
PubMed 22381354 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 4.81 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1950187 1 6.16
CHEMBL1950186 1 5.68
CHEMBL1950184 1 5.51
CHEMBL1950033 1 5.13
CHEMBL185 FLUOROURACIL 4.0 1 5.10
CHEMBL1950032 1 5.05
CHEMBL1950192 1 4.80
CHEMBL1950185 1 4.80
CHEMBL495700 1 4.75
CHEMBL1950180 1 4.75
CHEMBL495701 1 4.68
CHEMBL503014 1 4.64
CHEMBL1950031 1 4.64
CHEMBL1950181 1 4.62
CHEMBL122289 (Z)-Ajoene 1 4.60
CHEMBL1950182 1 4.58
CHEMBL496517 1 4.57
CHEMBL1950183 1 4.55
CHEMBL498176 1 4.48
CHEMBL445973 1 4.43
CHEMBL463217 1 4.42
CHEMBL122890 AJOENE 1 4.41
CHEMBL504085 1 4.17
CHEMBL1950191 1 -
CHEMBL1950188 1 -
CHEMBL1950190 1 -
CHEMBL1950189 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1950187 IC50 = 700.0 nM 6.16
CHEMBL1950186 IC50 = 2100.0 nM 5.68
CHEMBL1950184 IC50 = 3100.0 nM 5.51
CHEMBL1950033 IC50 = 7400.0 nM 5.13
CHEMBL185 FLUOROURACIL IC50 = 7900.0 nM 5.10
CHEMBL1950032 IC50 = 8900.0 nM 5.05
CHEMBL1950192 IC50 = 16000.0 nM 4.80
CHEMBL1950185 IC50 = 16000.0 nM 4.80
CHEMBL495700 IC50 = 18000.0 nM 4.75
CHEMBL1950180 IC50 = 18000.0 nM 4.75
CHEMBL495701 IC50 = 21000.0 nM 4.68
CHEMBL503014 IC50 = 23000.0 nM 4.64
CHEMBL1950031 IC50 = 23000.0 nM 4.64
CHEMBL1950181 IC50 = 24000.0 nM 4.62
CHEMBL122289 (Z)-Ajoene IC50 = 25000.0 nM 4.60
CHEMBL1950182 IC50 = 26000.0 nM 4.58
CHEMBL496517 IC50 = 27000.0 nM 4.57
CHEMBL1950183 IC50 = 28000.0 nM 4.55
CHEMBL498176 IC50 = 33000.0 nM 4.48
CHEMBL445973 IC50 = 37000.0 nM 4.43
CHEMBL463217 IC50 = 38000.0 nM 4.42
CHEMBL122890 AJOENE IC50 = 39000.0 nM 4.41
CHEMBL504085 IC50 = 68000.0 nM 4.17
CHEMBL1950191 IC50 > 200000.0 nM -
CHEMBL1950188 IC50 > 200000.0 nM -
CHEMBL1950190 IC50 > 200000.0 nM -
CHEMBL1950189 IC50 > 200000.0 nM -