Assay Detail
Binding
CHEMBL1955693
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Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate for 30 mins by continuous fluorimetric assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.73 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1950440 | — | — | 1 | 9.77 |
| CHEMBL1950444 | — | — | 1 | 9.43 |
| CHEMBL1950439 | — | — | 1 | 9.13 |
| CHEMBL1950443 | — | — | 1 | 9.00 |
| CHEMBL1950445 | — | — | 1 | 8.59 |
| CHEMBL1950309 | — | — | 1 | 8.30 |
| CHEMBL1950314 | — | — | 1 | 8.25 |
| CHEMBL1950441 | — | — | 1 | 8.18 |
| CHEMBL1950307 | — | — | 1 | 8.00 |
| CHEMBL1950311 | — | — | 1 | 7.85 |
| CHEMBL1950310 | — | — | 1 | 7.80 |
| CHEMBL1950308 | — | — | 1 | 7.42 |
| CHEMBL1950448 | — | — | 1 | 7.32 |
| CHEMBL1950451 | — | — | 1 | 7.22 |
| CHEMBL1950442 | — | — | 1 | 6.99 |
| CHEMBL1950446 | — | — | 1 | 6.80 |
| CHEMBL1950312 | — | — | 1 | 6.74 |
| CHEMBL1950449 | — | — | 1 | 6.65 |
| CHEMBL1950450 | — | — | 1 | 6.43 |
| CHEMBL1950313 | — | — | 1 | 6.37 |
| CHEMBL1950447 | — | — | 1 | 6.00 |
| CHEMBL1950452 | — | — | 1 | - |
| CHEMBL1950453 | — | — | 1 | - |
| CHEMBL1950454 | — | — | 1 | - |
| CHEMBL1950455 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1950440 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL1950444 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL1950439 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL1950443 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1950445 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1950309 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1950314 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1950441 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1950307 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1950311 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1950310 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1950308 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1950448 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1950451 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1950442 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL1950446 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1950312 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL1950449 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL1950450 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL1950313 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL1950447 | — | IC50 | = | 998.0 | nM | 6.00 |
| CHEMBL1950452 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1950453 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1950454 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1950455 | — | IC50 | > | 10000.0 | nM | - |