Assay Detail
Functional
CHEMBL1959031
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Growth inhibition of human LOX cells expressing B-Raf V600E mutant by MTT assay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LOX |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.75 | 7.75 |
| IC90 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956073 | — | — | 2 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956073 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1956073 | — | IC90 | = | 720.0 | nM | - |