Assay Detail
Binding
CHEMBL1959065
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Binding affinity to BRD4-BD1 by isothermal titration calorimetry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.37 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957266 | — | — | 1 | 7.31 |
| CHEMBL1958337 | — | — | 1 | 6.19 |
| CHEMBL661 | ALPRAZOLAM | 4.0 | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957266 | — | Kd | = | 49.0 | nM | 7.31 |
| CHEMBL1958337 | — | Kd | = | 640.0 | nM | 6.19 |
| CHEMBL661 | ALPRAZOLAM | Kd | = | 2460.0 | nM | 5.61 |