Assay Detail
Functional
CHEMBL1959116
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Cytotoxicity against human TF1 cells expressing wild type c-KIT assessed as cell viability after 72 hrs by resazurin dye based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TF-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
VX-322: a novel dual receptor tyrosine kinase inhibitor for the treatment of acute myelogenous leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.18 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1835870 | — | — | 1 | 8.80 |
| CHEMBL1835867 | — | — | 1 | 8.40 |
| CHEMBL1835747 | — | — | 1 | 7.75 |
| CHEMBL1835749 | — | — | 1 | 7.64 |
| CHEMBL1835743 | — | — | 1 | 6.12 |
| CHEMBL1835746 | — | — | 1 | 5.94 |
| CHEMBL1833992 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1835870 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1835867 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1835747 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1835749 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1835743 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1835746 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL1833992 | — | IC50 | = | 2300.0 | nM | 5.64 |