Assay Detail
Binding
CHEMBL1959283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFBB-induced PDGFRbeta autophosphorylation in human SF539 cells incubated for 60 mins prior to PDGFBB-induction measured after 10 mins by phosphotyrosine ELISA
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SF-539 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.31 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956890 | — | — | 1 | 5.82 |
| CHEMBL1956898 | — | — | 1 | 5.75 |
| CHEMBL7724 | AG1295 | — | 1 | 5.21 |
| CHEMBL1956893 | — | — | 1 | 4.47 |
| CHEMBL1956891 | — | — | 1 | - |
| CHEMBL1956888 | — | — | 1 | - |
| CHEMBL1956894 | — | — | 1 | - |
| CHEMBL1956896 | — | — | 1 | - |
| CHEMBL1956889 | — | — | 1 | - |
| CHEMBL1956895 | — | — | 1 | - |
| CHEMBL1956897 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956890 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1956898 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL7724 | AG1295 | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1956893 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL1956891 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1956888 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1956894 | — | IC50 | = | 229600.0 | nM | - |
| CHEMBL1956896 | — | IC50 | = | 212400.0 | nM | - |
| CHEMBL1956889 | — | IC50 | = | 159600.0 | nM | - |
| CHEMBL1956895 | — | IC50 | = | 129300.0 | nM | - |
| CHEMBL1956897 | — | IC50 | = | 129100.0 | nM | - |