Assay Detail
Functional
CHEMBL1959299
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Cytotoxicity against human A431 cells overexpressing EGFR
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.81 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1095464 | — | — | 1 | 5.92 |
| CHEMBL1095761 | — | — | 1 | 5.55 |
| CHEMBL1956887 | — | — | 1 | 4.63 |
| CHEMBL1956885 | — | — | 1 | 4.54 |
| CHEMBL499344 | — | — | 1 | 4.50 |
| CHEMBL502015 | — | — | 1 | 4.48 |
| CHEMBL1956886 | — | — | 1 | 4.47 |
| CHEMBL514014 | — | — | 1 | 4.38 |
| CHEMBL499345 | — | — | 1 | - |
| CHEMBL1095465 | — | — | 1 | - |
| CHEMBL474538 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1095464 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL1095761 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1956887 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL1956885 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL499344 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL502015 | — | IC50 | = | 33200.0 | nM | 4.48 |
| CHEMBL1956886 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL514014 | — | IC50 | = | 42100.0 | nM | 4.38 |
| CHEMBL499345 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1095465 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL474538 | — | IC50 | > | 50000.0 | nM | - |