Assay Detail
Functional
CHEMBL1959443
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Antiproliferative activity against human HCT116 cells after 3 days by WST-1 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.22 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957464 | — | — | 1 | 6.36 |
| CHEMBL1957463 | — | — | 1 | 6.31 |
| CHEMBL1957458 | — | — | 1 | 6.29 |
| CHEMBL1957459 | — | — | 1 | 6.28 |
| CHEMBL251819 | — | — | 1 | 6.25 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.12 |
| CHEMBL407420 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957464 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1957463 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1957458 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1957459 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL251819 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL407420 | — | IC50 | = | 1200.0 | nM | 5.92 |