Assay Detail
Binding
CHEMBL1959513
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Binding affinity to human adenosine A1 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A₂B adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.84 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485862 | — | — | 1 | 7.43 |
| CHEMBL260331 | — | — | 1 | 6.70 |
| CHEMBL273807 | — | — | 1 | 6.39 |
| CHEMBL260933 | GS 6201 | 1.0 | 1 | - |
| CHEMBL180693 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485862 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL260331 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL273807 | — | Ki | = | 403.0 | nM | 6.39 |
| CHEMBL260933 | GS 6201 | Ki | > | 10000.0 | nM | - |
| CHEMBL180693 | — | Ki | > | 10000.0 | nM | - |