Assay Detail
Functional
CHEMBL1959577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MEK in po dosed cynomolgus monkey peripheral blood mononuclear cells assessed as inhibition of PMA-stimulated ERK phosphorylation after 1 to 24 hrs by flow cytometry
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Macaca fascicularis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.85 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956073 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956073 | — | EC50 | = | 1410.0 | nM | 5.85 |