Assay Detail
Functional
CHEMBL1960049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as protection against virus-induced cytotoxicity after 5 days by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.29 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.52 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.27 |
| CHEMBL1957773 | — | — | 1 | 8.15 |
| CHEMBL1957770 | — | — | 1 | 8.09 |
| CHEMBL1957768 | — | — | 1 | 8.07 |
| CHEMBL1957769 | — | — | 1 | 8.06 |
| CHEMBL1957900 | — | — | 1 | 8.04 |
| CHEMBL1957903 | — | — | 1 | 8.03 |
| CHEMBL1957772 | — | — | 1 | 8.02 |
| CHEMBL1957906 | — | — | 1 | 8.01 |
| CHEMBL1957905 | — | — | 1 | 8.01 |
| CHEMBL1957902 | — | — | 1 | 8.00 |
| CHEMBL1957771 | — | — | 1 | 7.99 |
| CHEMBL1957901 | — | — | 1 | 7.95 |
| CHEMBL1957904 | — | — | 1 | 7.94 |
| CHEMBL1957907 | — | — | 1 | 7.72 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.69 |
| CHEMBL929 | DELAVIRDINE MESYLATE | 4.0 | 1 | 7.49 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.04 |
| CHEMBL1957910 | — | — | 1 | 6.65 |
| CHEMBL1957909 | — | — | 1 | 6.03 |
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 5.98 |
| CHEMBL1957913 | — | — | 1 | 5.78 |
| CHEMBL1957911 | — | — | 1 | 5.75 |
| CHEMBL1957914 | — | — | 1 | 5.75 |
| CHEMBL1957915 | — | — | 1 | 5.36 |
| CHEMBL1957912 | — | — | 1 | 4.44 |
| CHEMBL1957908 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1957773 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1957770 | — | EC50 | = | 8.2 | nM | 8.09 |
| CHEMBL1957768 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1957769 | — | EC50 | = | 8.8 | nM | 8.06 |
| CHEMBL1957900 | — | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL1957903 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL1957772 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL1957906 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL1957905 | — | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL1957902 | — | EC50 | = | 9.9 | nM | 8.00 |
| CHEMBL1957771 | — | EC50 | = | 10.2 | nM | 7.99 |
| CHEMBL1957901 | — | EC50 | = | 11.3 | nM | 7.95 |
| CHEMBL1957904 | — | EC50 | = | 11.5 | nM | 7.94 |
| CHEMBL1957907 | — | EC50 | = | 19.2 | nM | 7.72 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 20.6 | nM | 7.69 |
| CHEMBL929 | DELAVIRDINE MESYLATE | EC50 | = | 32.6 | nM | 7.49 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 90.1 | nM | 7.04 |
| CHEMBL1957910 | — | EC50 | = | 224.4 | nM | 6.65 |
| CHEMBL1957909 | — | EC50 | = | 931.6 | nM | 6.03 |
| CHEMBL853 | ZALCITABINE | EC50 | = | 1041.6 | nM | 5.98 |
| CHEMBL1957913 | — | EC50 | = | 1664.7 | nM | 5.78 |
| CHEMBL1957911 | — | EC50 | = | 1793.9 | nM | 5.75 |
| CHEMBL1957914 | — | EC50 | = | 1791.6 | nM | 5.75 |
| CHEMBL1957915 | — | EC50 | = | 4374.0 | nM | 5.36 |
| CHEMBL1957912 | — | EC50 | = | 36183.9 | nM | 4.44 |
| CHEMBL1957908 | — | EC50 | >= | 127050.2 | nM | - |