Assay Detail
Binding
CHEMBL1960317
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Inhibition of beta-casein-dependent canonical Wnt3 pathway in human HEK293T cells by luciferase reporter gene assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure-activity relationship study based on inhibitors for the Wnt response.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.95 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956334 | — | — | 1 | 8.70 |
| CHEMBL1956163 | — | — | 1 | 8.40 |
| CHEMBL1956329 | — | — | 1 | 8.40 |
| CHEMBL1956328 | — | — | 1 | 8.22 |
| CHEMBL1956343 | — | — | 1 | 7.64 |
| CHEMBL1956162 | — | — | 1 | 7.62 |
| CHEMBL562310 | — | — | 1 | 7.58 |
| CHEMBL1956340 | — | — | 1 | 7.43 |
| CHEMBL1086580 | — | — | 1 | 7.29 |
| CHEMBL1956314 | — | — | 1 | 7.26 |
| CHEMBL1956308 | — | — | 1 | 7.24 |
| CHEMBL1956327 | — | — | 1 | 7.17 |
| CHEMBL1956333 | — | — | 1 | 7.10 |
| CHEMBL1956318 | — | — | 1 | 7.03 |
| CHEMBL1956307 | — | — | 1 | 7.02 |
| CHEMBL1956315 | — | — | 1 | 6.96 |
| CHEMBL1956331 | — | — | 1 | 6.96 |
| CHEMBL1956313 | — | — | 1 | 6.92 |
| CHEMBL1956332 | — | — | 1 | 6.92 |
| CHEMBL1956341 | — | — | 1 | 6.82 |
| CHEMBL1956317 | — | — | 1 | 6.79 |
| CHEMBL1956342 | — | — | 1 | 6.77 |
| CHEMBL1956326 | — | — | 1 | 6.72 |
| CHEMBL1956330 | — | — | 1 | 6.71 |
| CHEMBL1956321 | — | — | 1 | 6.67 |
| CHEMBL1956337 | — | — | 1 | 6.50 |
| CHEMBL1956323 | — | — | 1 | 6.50 |
| CHEMBL1956336 | — | — | 1 | 6.38 |
| CHEMBL1956325 | — | — | 1 | 6.32 |
| CHEMBL1257089 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956334 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1956163 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1956329 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1956328 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1956343 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1956162 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL562310 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1956340 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1086580 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1956314 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1956308 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1956327 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1956333 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1956318 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1956307 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1956315 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL1956331 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL1956313 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL1956332 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1956341 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL1956317 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL1956342 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL1956326 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1956330 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL1956321 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL1956337 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL1956323 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL1956336 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL1956325 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL1257089 | — | IC50 | = | 538.0 | nM | 6.27 |
| CHEMBL1201303 | PYRVINIUM | IC50 | = | 592.0 | nM | 6.23 |
| CHEMBL1956335 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1956316 | — | IC50 | = | 604.0 | nM | 6.22 |
| CHEMBL1956339 | — | IC50 | = | 605.0 | nM | 6.22 |
| CHEMBL1956161 | — | IC50 | = | 728.0 | nM | 6.14 |
| CHEMBL1956338 | — | IC50 | = | 1176.0 | nM | 5.93 |
| CHEMBL1956306 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL1956309 | — | IC50 | - | — | - | |
| CHEMBL1956324 | — | IC50 | - | — | - | |
| CHEMBL1956322 | — | IC50 | - | — | - | |
| CHEMBL1956320 | — | IC50 | - | — | - | |
| CHEMBL1956319 | — | IC50 | - | — | - | |
| CHEMBL1956312 | — | IC50 | - | — | - | |
| CHEMBL1956311 | — | IC50 | - | — | - | |
| CHEMBL1956310 | — | IC50 | - | — | - |