Assay Detail
Functional
CHEMBL1960330
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Cytotoxicity against human SCC114 cells by phenotype-based spindle multipolarity assay
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SCC114 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Disparate SAR data of griseofulvin analogues for the dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 8 | - | - |
| IC50 | 1 | 4.70 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562 | GRISEOFULVIN | 4.0 | 1 | 4.70 |
| CHEMBL522127 | ISOGRISEOFULVIN | — | 1 | - |
| CHEMBL522427 | — | — | 1 | - |
| CHEMBL1956524 | — | — | 1 | - |
| CHEMBL1956525 | — | — | 1 | - |
| CHEMBL1956526 | — | — | 1 | - |
| CHEMBL1956527 | — | — | 1 | - |
| CHEMBL1956528 | — | — | 1 | - |
| CHEMBL1956529 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562 | GRISEOFULVIN | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL522127 | ISOGRISEOFULVIN | Inhibition | - | % | - | |
| CHEMBL522427 | — | Inhibition | - | % | - | |
| CHEMBL1956524 | — | Inhibition | - | % | - | |
| CHEMBL1956525 | — | Inhibition | - | % | - | |
| CHEMBL1956526 | — | Inhibition | - | % | - | |
| CHEMBL1956527 | — | Inhibition | - | % | - | |
| CHEMBL1956528 | — | Inhibition | - | % | - | |
| CHEMBL1956529 | — | Inhibition | - | % | - |