Assay Detail
Functional
CHEMBL1960486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at androgen receptor expressed in Cos7 cells after 24 hrs by luciferase reporter gene assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.96 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957612 | — | — | 1 | 5.96 |
| CHEMBL1957721 | — | — | 1 | - |
| CHEMBL1957613 | — | — | 1 | - |
| CHEMBL1957614 | — | — | 1 | - |
| CHEMBL1957615 | — | — | 1 | - |
| CHEMBL1957616 | — | — | 1 | - |
| CHEMBL1957617 | — | — | 1 | - |
| CHEMBL1957618 | — | — | 1 | - |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 1 | - |
| CHEMBL1957619 | — | — | 1 | - |
| CHEMBL1957620 | — | — | 1 | - |
| CHEMBL1957621 | — | — | 1 | - |
| CHEMBL1957622 | — | — | 1 | - |
| CHEMBL1957607 | — | — | 1 | - |
| CHEMBL1957722 | — | — | 1 | - |
| CHEMBL1957608 | — | — | 1 | - |
| CHEMBL1957609 | — | — | 1 | - |
| CHEMBL1957610 | — | — | 1 | - |
| CHEMBL1957723 | — | — | 1 | - |
| CHEMBL1957724 | — | — | 1 | - |
| CHEMBL1957725 | — | — | 1 | - |
| CHEMBL1957611 | — | — | 1 | - |
| CHEMBL1957726 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957612 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1957721 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957613 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957614 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957615 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957616 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957617 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957618 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL409 | BICALUTAMIDE | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957619 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957620 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957621 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957622 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957607 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957722 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957608 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957609 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957610 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957723 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957724 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957725 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957611 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957726 | — | EC50 | > | 10000.0 | nM | - |