Assay Detail
Binding
CHEMBL1960500
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Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins to 72 hrs measured after 15 mins by stopped flow CO2 hydration method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.42 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL186422 | — | — | 1 | 6.38 |
| CHEMBL1955873 | THIOBENZOIC ACID | — | 1 | 5.24 |
| CHEMBL1200471 | PYRITHIONE ZINC | 4.0 | 1 | 5.11 |
| CHEMBL508338 | THIMEROSAL | 3.0 | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL186422 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL1955873 | THIOBENZOIC ACID | Ki | = | 5740.0 | nM | 5.24 |
| CHEMBL1200471 | PYRITHIONE ZINC | Ki | = | 7760.0 | nM | 5.11 |
| CHEMBL508338 | THIMEROSAL | Ki | = | 10900.0 | nM | 4.96 |