Assay Detail
Binding
CHEMBL1961032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) (CHEMBL2111377) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Aminopyrimidinone cdc7 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.65 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1958411 | — | — | 1 | 7.82 |
| CHEMBL1958405 | — | — | 1 | 7.22 |
| CHEMBL1958414 | — | — | 1 | 7.22 |
| CHEMBL1958412 | — | — | 1 | 6.84 |
| CHEMBL1958413 | — | — | 1 | 6.75 |
| CHEMBL1958415 | — | — | 1 | 6.52 |
| CHEMBL1958416 | — | — | 1 | 6.52 |
| CHEMBL1958420 | — | — | 1 | 6.52 |
| CHEMBL1958418 | — | — | 1 | 6.39 |
| CHEMBL1958419 | — | — | 1 | 5.75 |
| CHEMBL1958417 | — | — | 1 | 5.58 |
| CHEMBL1958421 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1958411 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1958405 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1958414 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1958412 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL1958413 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1958415 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1958416 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1958420 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1958418 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1958419 | — | EC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL1958417 | — | EC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL1958421 | — | EC50 | - | — | - |