Assay Detail
Functional
CHEMBL1961049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against multidrug-resistant HIV 1 IRLL98 harboring reverse transcriptase K101Q/Y181C/G190a mutant infected in human MT4 cells assessed as virus-induced cytopathic effect after 5 days by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.92 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 9.52 |
| CHEMBL1956096 | — | — | 1 | 9.09 |
| CHEMBL1956088 | — | — | 1 | 8.11 |
| CHEMBL240386 | — | — | 1 | 6.69 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.20 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1956096 | — | EC50 | = | 0.82 | nM | 9.09 |
| CHEMBL1956088 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL240386 | — | EC50 | = | 204.6 | nM | 6.69 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 633.5 | nM | 6.20 |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 18850.0 | nM | - |