Assay Detail
Functional
CHEMBL1961052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV 1 harboring reverse transcriptase Y181C mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.17 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 8.92 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.00 |
| CHEMBL240386 | — | — | 1 | 7.85 |
| CHEMBL1956096 | — | — | 1 | 7.40 |
| CHEMBL1956092 | — | — | 1 | 7.37 |
| CHEMBL1956088 | — | — | 1 | 7.36 |
| CHEMBL1956095 | — | — | 1 | 7.35 |
| CHEMBL1956091 | — | — | 1 | 7.35 |
| CHEMBL1956084 | — | — | 1 | 7.34 |
| CHEMBL1956089 | — | — | 1 | 7.22 |
| CHEMBL1956094 | — | — | 1 | 7.15 |
| CHEMBL1956093 | — | — | 1 | 7.15 |
| CHEMBL1956083 | — | — | 1 | 7.06 |
| CHEMBL1956087 | — | — | 1 | 6.81 |
| CHEMBL1956082 | — | — | 1 | 6.46 |
| CHEMBL1956090 | — | — | 1 | 6.45 |
| CHEMBL1956085 | — | — | 1 | 6.25 |
| CHEMBL1956086 | — | — | 1 | 5.60 |
| CHEMBL1955868 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 10.1 | nM | 8.00 |
| CHEMBL240386 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1956096 | — | EC50 | = | 39.9 | nM | 7.40 |
| CHEMBL1956092 | — | EC50 | = | 42.5 | nM | 7.37 |
| CHEMBL1956088 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1956095 | — | EC50 | = | 44.7 | nM | 7.35 |
| CHEMBL1956091 | — | EC50 | = | 44.3 | nM | 7.35 |
| CHEMBL1956084 | — | EC50 | = | 45.58 | nM | 7.34 |
| CHEMBL1956089 | — | EC50 | = | 60.2 | nM | 7.22 |
| CHEMBL1956094 | — | EC50 | = | 70.3 | nM | 7.15 |
| CHEMBL1956093 | — | EC50 | = | 71.4 | nM | 7.15 |
| CHEMBL1956083 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL1956087 | — | EC50 | = | 153.7 | nM | 6.81 |
| CHEMBL1956082 | — | EC50 | = | 344.0 | nM | 6.46 |
| CHEMBL1956090 | — | EC50 | = | 357.7 | nM | 6.45 |
| CHEMBL1956085 | — | EC50 | = | 561.0 | nM | 6.25 |
| CHEMBL1956086 | — | EC50 | = | 2535.0 | nM | 5.60 |
| CHEMBL1955868 | — | EC50 | > | 2838.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 7510.0 | nM | - |