Assay Detail
Functional
CHEMBL1961053
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV 1 harboring reverse transcriptase Y188L mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.70 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956096 | — | — | 1 | 7.56 |
| CHEMBL1956092 | — | — | 1 | 7.50 |
| CHEMBL240386 | — | — | 1 | 7.30 |
| CHEMBL1956088 | — | — | 1 | 7.22 |
| CHEMBL1956095 | — | — | 1 | 7.18 |
| CHEMBL1956091 | — | — | 1 | 7.00 |
| CHEMBL1956093 | — | — | 1 | 6.97 |
| CHEMBL1956094 | — | — | 1 | 6.82 |
| CHEMBL1956089 | — | — | 1 | 6.65 |
| CHEMBL1956084 | — | — | 1 | 6.64 |
| CHEMBL70663 | DAPIVIRINE | 3.0 | 1 | 6.48 |
| CHEMBL1956083 | — | — | 1 | 6.18 |
| CHEMBL1956087 | — | — | 1 | 6.08 |
| CHEMBL1956090 | — | — | 1 | 5.99 |
| CHEMBL1956085 | — | — | 1 | 5.85 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 5.79 |
| CHEMBL1955868 | — | — | 1 | - |
| CHEMBL1956082 | — | — | 1 | - |
| CHEMBL1956086 | — | — | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956096 | — | EC50 | = | 27.4 | nM | 7.56 |
| CHEMBL1956092 | — | EC50 | = | 31.4 | nM | 7.50 |
| CHEMBL240386 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1956088 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1956095 | — | EC50 | = | 66.6 | nM | 7.18 |
| CHEMBL1956091 | — | EC50 | = | 100.2 | nM | 7.00 |
| CHEMBL1956093 | — | EC50 | = | 108.2 | nM | 6.97 |
| CHEMBL1956094 | — | EC50 | = | 151.1 | nM | 6.82 |
| CHEMBL1956089 | — | EC50 | = | 224.9 | nM | 6.65 |
| CHEMBL1956084 | — | EC50 | = | 230.4 | nM | 6.64 |
| CHEMBL70663 | DAPIVIRINE | EC50 | = | 333.9 | nM | 6.48 |
| CHEMBL1956083 | — | EC50 | = | 652.8 | nM | 6.18 |
| CHEMBL1956087 | — | EC50 | = | 836.1 | nM | 6.08 |
| CHEMBL1956090 | — | EC50 | = | 1016.8 | nM | 5.99 |
| CHEMBL1956085 | — | EC50 | = | 1401.0 | nM | 5.85 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 1615.0 | nM | 5.79 |
| CHEMBL1955868 | — | EC50 | > | 2838.0 | nM | - |
| CHEMBL1956082 | — | EC50 | > | 2500.0 | nM | - |
| CHEMBL1956086 | — | EC50 | > | 2697.0 | nM | - |
| CHEMBL57 | NEVIRAPINE | EC50 | > | 7510.0 | nM | - |