Assay Detail
Binding
CHEMBL1961261
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Inhibition of human carbonic anhydrase 1 after 6 hrs by stop-flow CO2 hydration assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 4.78 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6466 | COUMARIN | 4.0 | 1 | 5.51 |
| CHEMBL270672 | — | — | 1 | 5.25 |
| CHEMBL1957177 | — | — | 1 | 5.14 |
| CHEMBL1957182 | — | — | 1 | 5.12 |
| CHEMBL1957176 | — | — | 1 | 5.12 |
| CHEMBL1955879 | — | — | 1 | 5.10 |
| CHEMBL1957179 | — | — | 1 | 5.09 |
| CHEMBL1957178 | — | — | 1 | 5.08 |
| CHEMBL1957181 | — | — | 1 | 5.07 |
| CHEMBL1957175 | — | — | 1 | 5.06 |
| CHEMBL1957183 | — | — | 1 | 5.03 |
| CHEMBL1957184 | — | — | 1 | 4.61 |
| CHEMBL1957172 | — | — | 1 | 4.52 |
| CHEMBL1957187 | — | — | 1 | 4.41 |
| CHEMBL1957180 | — | — | 1 | 4.37 |
| CHEMBL1957186 | — | — | 1 | 4.37 |
| CHEMBL1951641 | — | — | 1 | 4.32 |
| CHEMBL1957185 | — | — | 1 | 4.18 |
| CHEMBL432745 | 7-ALLYLOXYCOUMARIN | — | 1 | 4.14 |
| CHEMBL1957188 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6466 | COUMARIN | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL270672 | — | Ki | = | 5560.0 | nM | 5.25 |
| CHEMBL1957177 | — | Ki | = | 7170.0 | nM | 5.14 |
| CHEMBL1957182 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL1957176 | — | Ki | = | 7570.0 | nM | 5.12 |
| CHEMBL1955879 | — | Ki | = | 8020.0 | nM | 5.10 |
| CHEMBL1957179 | — | Ki | = | 8180.0 | nM | 5.09 |
| CHEMBL1957178 | — | Ki | = | 8320.0 | nM | 5.08 |
| CHEMBL1957181 | — | Ki | = | 8510.0 | nM | 5.07 |
| CHEMBL1957175 | — | Ki | = | 8780.0 | nM | 5.06 |
| CHEMBL1957183 | — | Ki | = | 9240.0 | nM | 5.03 |
| CHEMBL1957184 | — | Ki | = | 24400.0 | nM | 4.61 |
| CHEMBL1957172 | — | Ki | = | 30300.0 | nM | 4.52 |
| CHEMBL1957187 | — | Ki | = | 38800.0 | nM | 4.41 |
| CHEMBL1957180 | — | Ki | = | 43200.0 | nM | 4.37 |
| CHEMBL1957186 | — | Ki | = | 42900.0 | nM | 4.37 |
| CHEMBL1951641 | — | Ki | = | 47700.0 | nM | 4.32 |
| CHEMBL1957185 | — | Ki | = | 66300.0 | nM | 4.18 |
| CHEMBL432745 | 7-ALLYLOXYCOUMARIN | Ki | = | 72900.0 | nM | 4.14 |
| CHEMBL1957188 | — | Ki | = | 91700.0 | nM | 4.04 |