Assay Detail
Binding
CHEMBL1961333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by scintillation counting
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP4 subtype (CHEMBL2489) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 8.52 | 10.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957437 | — | — | 1 | 10.92 |
| CHEMBL1933722 | — | — | 1 | 9.39 |
| CHEMBL1933724 | — | — | 1 | 9.30 |
| CHEMBL1933719 | — | — | 1 | 9.22 |
| CHEMBL1957430 | — | — | 1 | 9.10 |
| CHEMBL1957434 | — | — | 1 | 9.10 |
| CHEMBL1957436 | — | — | 1 | 9.09 |
| CHEMBL1933718 | — | — | 1 | 9.05 |
| CHEMBL1957435 | — | — | 1 | 9.03 |
| CHEMBL1933725 | — | — | 1 | 8.82 |
| CHEMBL222715 | — | — | 1 | 8.77 |
| CHEMBL1933717 | — | — | 1 | 8.74 |
| CHEMBL223151 | — | — | 1 | 8.70 |
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 8.51 |
| CHEMBL1933723 | — | — | 1 | 8.26 |
| CHEMBL1957308 | — | — | 1 | 8.05 |
| CHEMBL42027 | — | — | 1 | 8.04 |
| CHEMBL1933721 | — | — | 1 | 7.92 |
| CHEMBL1933720 | — | — | 1 | 7.46 |
| CHEMBL1957433 | — | — | 1 | 7.28 |
| CHEMBL1957432 | — | — | 1 | 7.11 |
| CHEMBL1957431 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957437 | — | Ki | = | 0.012 | nM | 10.92 |
| CHEMBL1933722 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL1933724 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1933719 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1957430 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL1957434 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL1957436 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL1933718 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1957435 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL1933725 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL222715 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1933717 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL223151 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL548 | DINOPROSTONE | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL1933723 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL1957308 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL42027 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL1933721 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1933720 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL1957433 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL1957432 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL1957431 | — | Ki | = | 3000.0 | nM | 5.52 |