Assay Detail
Functional
CHEMBL1963713
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MARK4
38
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Category | other |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
MAP/microtubule affinity-regulating kinase 4 (CHEMBL5754) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PubChem BioAssay data set
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 38 | 7.00 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1993661 | — | — | 1 | 9.30 |
| CHEMBL1980995 | — | — | 1 | 9.10 |
| CHEMBL592030 | — | — | 1 | 8.10 |
| CHEMBL1972346 | — | — | 1 | 7.30 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 7.30 |
| CHEMBL1998953 | — | — | 1 | 7.10 |
| CHEMBL475251 | R-406 | 2.0 | 1 | 7.00 |
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 7.00 |
| CHEMBL191003 | JNJ-7706621 | — | 1 | 7.00 |
| CHEMBL1974328 | — | — | 1 | 6.60 |
| CHEMBL458997 | — | — | 1 | 6.40 |
| CHEMBL1991674 | — | — | 1 | 6.40 |
| CHEMBL234085 | — | — | 1 | 6.20 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.00 |
| CHEMBL1982753 | — | — | 1 | 5.80 |
| CHEMBL377408 | — | — | 1 | 5.40 |
| CHEMBL10 | SB-203580 | — | 1 | - |
| CHEMBL406845 | — | — | 1 | - |
| CHEMBL415049 | BARASERTIB | 3.0 | 1 | - |
| CHEMBL278041 | SB-202190 | — | 1 | - |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | - |
| CHEMBL124660 | TANDUTINIB | 2.0 | 1 | - |
| CHEMBL1984038 | — | — | 1 | - |
| CHEMBL259084 | MLN-8054 | 1.0 | 1 | - |
| CHEMBL1978166 | — | — | 2 | - |
| CHEMBL939 | GEFITINIB | 4.0 | 2 | - |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | - |
| CHEMBL574738 | AST-487 | 1.0 | 1 | - |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | - |
| CHEMBL1990885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1993661 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL1980995 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL592030 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL1972346 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL1084546 | PF-00562271 | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL1998953 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL475251 | R-406 | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL191003 | JNJ-7706621 | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL522892 | DOVITINIB | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1974328 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL458997 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL1991674 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL234085 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL572878 | TOZASERTIB | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1982753 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL377408 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL223360 | LINIFANIB | Ki | > | 5011.87 | nM | - |
| CHEMBL941 | IMATINIB | Ki | > | 5011.87 | nM | - |
| CHEMBL5416410 | DASATINIB | Ki | > | 5011.87 | nM | - |
| CHEMBL119385 | NEFLAMAPIMOD | Ki | > | 5011.87 | nM | - |
| CHEMBL1990496 | — | Ki | > | 5011.87 | nM | - |
| CHEMBL424872 | — | Ki | > | 5011.87 | nM | - |
| CHEMBL1990885 | — | Ki | > | 5011.87 | nM | - |
| CHEMBL103667 | DORAMAPIMOD | Ki | > | 5011.87 | nM | - |
| CHEMBL574738 | AST-487 | Ki | > | 5011.87 | nM | - |
| CHEMBL296468 | BMS-387032 | Ki | > | 5011.87 | nM | - |
| CHEMBL939 | GEFITINIB | Ki | > | 5011.87 | nM | - |
| CHEMBL415049 | BARASERTIB | Ki | > | 5011.87 | nM | - |
| CHEMBL259084 | MLN-8054 | Ki | > | 5011.87 | nM | - |
| CHEMBL278041 | SB-202190 | Ki | > | 5011.87 | nM | - |
| CHEMBL1978166 | — | Ki | > | 5011.87 | nM | - |
| CHEMBL1978166 | — | Ki | > | 5011.87 | nM | - |
| CHEMBL939 | GEFITINIB | Ki | > | 5011.87 | nM | - |
| CHEMBL124660 | TANDUTINIB | Ki | > | 5011.87 | nM | - |
| CHEMBL1984038 | — | Ki | > | 5011.87 | nM | - |
| CHEMBL1336 | SORAFENIB | Ki | > | 5011.87 | nM | - |
| CHEMBL10 | SB-203580 | Ki | > | 5011.87 | nM | - |
| CHEMBL406845 | — | Ki | > | 5011.87 | nM | - |