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Assay Detail

CHEMBL1963755

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CAMKK2
ChEMBL ↗
38
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Calcium/calmodulin-dependent protein kinase kinase 2 (CHEMBL5284) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 38 7.29 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 9.70
CHEMBL1993661 — — 1 8.90
CHEMBL458997 — — 1 8.90
CHEMBL191003 JNJ-7706621 — 1 7.20
CHEMBL1972346 — — 1 7.20
CHEMBL1974328 — — 1 6.80
CHEMBL522892 DOVITINIB 3.0 1 6.80
CHEMBL1084546 PF-00562271 1.0 1 6.50
CHEMBL1990885 — — 1 6.20
CHEMBL574738 AST-487 1.0 1 6.10
CHEMBL1998953 — — 1 5.90
CHEMBL592030 — — 1 -
CHEMBL103667 DORAMAPIMOD 2.0 1 -
CHEMBL296468 BMS-387032 1.0 1 -
CHEMBL939 GEFITINIB 4.0 2 -
CHEMBL1982753 — — 1 -
CHEMBL1978166 — — 2 -
CHEMBL259084 MLN-8054 1.0 1 -
CHEMBL572878 TOZASERTIB 2.0 1 -
CHEMBL124660 TANDUTINIB 2.0 1 -
CHEMBL1984038 — — 1 -
CHEMBL1336 SORAFENIB 4.0 1 -
CHEMBL406845 — — 1 -
CHEMBL10 SB-203580 — 1 -
CHEMBL1991674 — — 1 -
CHEMBL415049 BARASERTIB 3.0 1 -
CHEMBL475251 R-406 2.0 1 -
CHEMBL278041 SB-202190 — 1 -
CHEMBL234085 — — 1 -
CHEMBL377408 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 0.1995 nM 9.70
CHEMBL1993661 — Ki = 1.259 nM 8.90
CHEMBL458997 — Ki = 1.259 nM 8.90
CHEMBL191003 JNJ-7706621 Ki = 63.1 nM 7.20
CHEMBL1972346 — Ki = 63.1 nM 7.20
CHEMBL1974328 — Ki = 158.49 nM 6.80
CHEMBL522892 DOVITINIB Ki = 158.49 nM 6.80
CHEMBL1084546 PF-00562271 Ki = 316.23 nM 6.50
CHEMBL1990885 — Ki = 630.96 nM 6.20
CHEMBL574738 AST-487 Ki = 794.33 nM 6.10
CHEMBL1998953 — Ki = 1258.93 nM 5.90
CHEMBL259084 MLN-8054 Ki > 2511.89 nM -
CHEMBL223360 LINIFANIB Ki > 2511.89 nM -
CHEMBL1982753 — Ki > 2511.89 nM -
CHEMBL415049 BARASERTIB Ki > 2511.89 nM -
CHEMBL939 GEFITINIB Ki > 2511.89 nM -
CHEMBL296468 BMS-387032 Ki > 2511.89 nM -
CHEMBL103667 DORAMAPIMOD Ki > 2511.89 nM -
CHEMBL592030 — Ki > 2511.89 nM -
CHEMBL424872 — Ki > 2511.89 nM -
CHEMBL1990496 — Ki > 2511.89 nM -
CHEMBL119385 NEFLAMAPIMOD Ki > 2511.89 nM -
CHEMBL5416410 DASATINIB Ki > 2511.89 nM -
CHEMBL941 IMATINIB Ki > 2511.89 nM -
CHEMBL572878 TOZASERTIB Ki > 2511.89 nM -
CHEMBL377408 — Ki > 2511.89 nM -
CHEMBL124660 TANDUTINIB Ki > 2511.89 nM -
CHEMBL1984038 — Ki > 2511.89 nM -
CHEMBL1336 SORAFENIB Ki > 2511.89 nM -
CHEMBL406845 — Ki > 2511.89 nM -
CHEMBL10 SB-203580 Ki > 2511.89 nM -
CHEMBL1991674 — Ki > 2511.89 nM -
CHEMBL475251 R-406 Ki > 2511.89 nM -
CHEMBL1978166 — Ki > 2511.89 nM -
CHEMBL939 GEFITINIB Ki > 2511.89 nM -
CHEMBL1978166 — Ki > 2511.89 nM -
CHEMBL278041 SB-202190 Ki > 2511.89 nM -
CHEMBL234085 — Ki > 2511.89 nM -